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Search Results for " growth hormone receptor "

Targets

39

Compounds

3

Natural Products

19

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T17103 TM-N1324 Others , GHSR
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s...
T4648 TC-G-1008 GPR39-C3 GHSR
TC-G-1008 (GPR39-C3) is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively).
TQ0022 Capromorelin Tartrate CP 424391-18 GHSR
Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).
T16508 PF-5190457 PF-05190457 GHSR
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
T10319 Anamorelin RC-1291,ONO-7643 GHSR
Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).
T7112 Ibutamoren Mesylate MK-0677,MK-677 GHSR
Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
T7225 AnaMorelin hydrochloride RC-1291 hydrochloride,ONO-7643 hydrochloride GHSR
AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).
T34281 Relamorelin BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131 GHSR
Relamorelin (RM-131), a selective and potent growth hormone-releasing peptide/growth hormone secretagogue receptor (GHSR) agonist, is a potent growth hormone-releasing peptide mimetic with a high affinity for the GHS-1a ...
TP2236L Cortistatin-8 acetate Cortistatin-8 acetate(485803-62-1 Free base) GHSR
Cortistatin-8 acetate is a corticosteroid analog, a GHS-R antagonist with inhibitory effects on the growth hormone pro-secretin receptor.Cortistatin-8 acetate is a synthetic corticosteroid-derived ligand for the growth h...
TP1155L Human growth hormone-releasing factor acetate GHSR
Human growth hormone-releasing factor acetate is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1].
T11719 JMV 2959 hydrochloride (925238-89-7 free base) JMV 2959 hydrochloride GHSR
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
T3630 Relugolix RVT-601,TAK-385 GNRH Receptor
Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi...
TP1570 Cortistatin-14 Somatostatin
Cortistatin-14, a neuropeptide structurally similar to growth inhibitor-14, has anticonvulsant and neuroprotective effects and impairs recognition memory consolidation in mice through activation of sst(2), growth hormone...
T1167 Cyproterone acetate Androcur,Cyproterone 17-O-acetate Androgen Receptor
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ...
T11798 L-692429 MK-0751 GHSR , GPCR19
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by glucocorticoids.L-692429 has a high affinity for the G prot...
T31734 BMS-604992 EX1314,EX-1314 HCl,EX-1314,BMS604992,EX-1314 hydrochloride, BMS-604992,EX 1314
EX-1314 (BMS-604992) is a growth hormone secretagogue receptor (GHSR) agonist.
T28812 SM-130686 SM 130686,SM130,686,SM 130,686
SM-130,686 is a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue. It has around half the potency of the endogenous agonist ghrelin as a stimulator o...
T75713 Human growth hormone-releasing factor TFA
Human Growth Hormone-Releasing Factor TFA, also known as Growth Hormone-Releasing Factor Human TFA, is a hypothalamic polypeptide that promotes the production and release of growth hormone (GH) through its interaction wi...
T76318 GHRF, porcine
GHRF, porcine, a growth hormone releasing factor (GHRF) peptide (porcine), binds to the growth hormone secretagogue receptor (GHSR), thereby inducing the release of growth hormone [1] [2].
T11719L JMV 2959 Others
JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).
TP1155 Human growth hormone-releasing factor Growth Hormone Releasing Factor human
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothal...
T76317 [His1,Nle27] GHRF (1-32), amide, human
[His1,Nle27] GHRF (1-32), amide, human is a synthetic analog of the growth hormone-releasing hormone (GHRH), characterized by its enhanced affinity for the growth hormone-releasing hormone receptor (GHRHR) [1].
T28366 PF-04628935 PF 04628935,PF 4628935,PF4628935,PF04628935,PF-4628935
PF-04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. PF-04628935 is orally bioavailable and brain penetrant.
T35793 JMV3002 JMV3002
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrel...
T39236 Relamorelin acetate Relamorelin acetate,RM-131 acetate,BIM-28131acetate
Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki v...
T75157 Cimdelirsen
Cimdelirsen, a novel ligand-conjugated, hepatic-targeted antisense oligonucleotide under investigation, aims to diminish growth hormone receptor (GHr) synthesis. This inhibits the harmful effects of growth hormone (GH) h...
T68276 Macimorelin acetate EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate
Macimorelin Acetate (EP-1572), an orally active growth hormone (GH) secretagogue and a ghrelin receptor (GHSR) agonist, stimulates GH release. It is utilized in research focusing on adult growth hormone deficiency (AGHD)...
T75157L Cimdelirsen sodium
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH...
T82498 Eftansomatropin alfa
Eftansomatropin alfa, an antibody that targets the growth hormone receptor (GSH), is a fusion protein comprising GH1 and the Fc region of IGHG4 [1].
T38959 BMS-604992 dihydrochloride EX-1314 dihydrochloride,BMS-604992 dihydrochloride
BMS-604992 (EX-1314) dihydrochloride is a selective and orally active small-molecule agonist of the growth hormone secretagogue receptor (GHSR). It exhibits high-affinity binding (k i = 2.3 nM) and potent functional acti...
T40876 BMS-604992 free base BMS-604992 free base,EX-1314 free base
BMS-604992 (EX-1314) free base is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. It exhibits high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0....
T64119 SSTR5 antagonist 2 hydrochloride
SSTR5 antagonist 2 hydrochloride is a potent, orally active, selective growth hormone inhibitory hormone (receptor) subtype 5 (SSTR5) antagonist that has shown potential for investigation in type 2 diabetes.
T83756 S1H TFA Site 1-binding Helix
S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered b...
T35524 (1S)-Calcitriol
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3), a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), exerts potent actions through vitamin D receptor (VDR) activation, including the inhibition of keratin...
T37412 AZ-GHS-22
AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in ...
T75262 Relamorelin TFA
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, acts as a potent and selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR), with a K_i of 0.42 nM for the GHS-1a receptor. This compound is...
T75928 Des-​Gln14-​Ghrelin TFA
Des-Gln14-Ghrelin TFA serves as a potent endogenous ligand for the growth hormone secretagogue receptor, effectively inducing increases in intracellular calcium levels ([Ca2+]i) in CHO-GHSR62 cells with an EC50 of 2.4 nM...
TP1532 γ-2-MSH (41-58), amide
Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cel...
T78003 [D-p-Cl-Phe6,Leu17]-VIP TFA
[D-p-Cl-Phe6,Leu17]-VIP TFA acts as a competitive and selective antagonist of the vasoactive intestinal peptide (VIP) receptor, exhibiting an IC50 of 125.8 nM. It shows no activity on glucagon, secretin, or growth hormon...

Compounds

TM-N1324
T17103
Synonym:
Target: Others, GHSR
TC-G-1008
T4648
Synonym: GPR39-C3
Target: GHSR
Capromorelin Tartrate
TQ0022
Synonym: CP 424391-18
Target: GHSR
PF-5190457
T16508
Synonym: PF-05190457
Target: GHSR
Anamorelin
T10319
Synonym: RC-1291,ONO-7643
Target: GHSR
Ibutamoren Mesylate
T7112
Synonym: MK-0677,MK-677
Target: GHSR
AnaMorelin hydrochloride
T7225
Synonym: RC-1291 hydrochloride,ONO-7643 hydrochloride
Target: GHSR
Relamorelin
T34281
Synonym: BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131
Target: GHSR
Cortistatin-8 acetate
TP2236L
Synonym: Cortistatin-8 acetate(485803-62-1 Free base)
Target: GHSR
Human growth hormone-releasing factor acetate
TP1155L
Synonym:
Target: GHSR
JMV 2959 hydrochloride (925238-89-7 free base)
T11719
Synonym: JMV 2959 hydrochloride
Target: GHSR
Relugolix
T3630
Synonym: RVT-601,TAK-385
Target: GNRH Receptor
Cortistatin-14
TP1570
Synonym:
Target: Somatostatin
Cyproterone acetate
T1167
Synonym: Androcur,Cyproterone 17-O-acetate
Target: Androgen Receptor
L-692429
T11798
Synonym: MK-0751
Target: GHSR, GPCR19
BMS-604992
T31734
Synonym: EX1314,EX-1314 HCl,EX-1314,BMS604992,EX-1314 hydrochloride, BMS-604992,EX 1314
Target:
SM-130686
T28812
Synonym: SM 130686,SM130,686,SM 130,686
Target:
Human growth hormone-releasing factor TFA
T75713
Synonym:
Target:
GHRF, porcine
T76318
Synonym:
Target:
JMV 2959
T11719L
Synonym:
Target: Others
Human growth hormone-releasing factor
TP1155
Synonym: Growth Hormone Releasing Factor human
Target:
[His1,Nle27] GHRF (1-32), amide, human
T76317
Synonym:
Target:
PF-04628935
T28366
Synonym: PF 04628935,PF 4628935,PF4628935,PF04628935,PF-4628935
Target:
JMV3002
T35793
Synonym: JMV3002
Target:
Relamorelin acetate
T39236
Synonym: Relamorelin acetate,RM-131 acetate,BIM-28131acetate
Target:
Cimdelirsen
T75157
Synonym:
Target:
Macimorelin acetate
T68276
Synonym: EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate
Target:
Cimdelirsen sodium
T75157L
Synonym:
Target:
Eftansomatropin alfa
T82498
Synonym:
Target:
BMS-604992 dihydrochloride
T38959
Synonym: EX-1314 dihydrochloride,BMS-604992 dihydrochloride
Target:
BMS-604992 free base
T40876
Synonym: BMS-604992 free base,EX-1314 free base
Target:
SSTR5 antagonist 2 hydrochloride
T64119
Synonym:
Target:
S1H TFA
T83756
Synonym: Site 1-binding Helix
Target:
(1S)-Calcitriol
T35524
Synonym:
Target:
AZ-GHS-22
T37412
Synonym:
Target:
Relamorelin TFA
T75262
Synonym:
Target:
des-​Gln14-​Ghrelin TFA
T75928
Synonym:
Target:
γ-2-MSH (41-58), amide
TP1532
Synonym:
Target:
[D-p-Cl-Phe6,Leu17]-VIP TFA
T78003
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T7931 16a,17a-Epoxy-4-Pregnen-3,20-Dione Others
16a,17a-Epoxy-4-Pregnen-3,20-Dione is a synthetic progestin, a metabolite of the luteinizing hormone hormone, which acts by binding to the luteinizing hormone receptor. It has been used to study the effects of progestero...
T80006 Emoghrelin GHSR
Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].
T82277 GM1a Ganglioside oligosaccharide
GM1a Ganglioside oligosaccharide, a semisynthetic derivative of ganglioside GM1, serves as the natural receptor for cholera toxin and is crucial for both general growth regulation and the coupling of hormone-induced resp...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04281 GHR/Growth Hormone R Protein, Rat, Recombinant (hFc) Rat HEK293 Cells
GHR/Growth Hormone R Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55.4 kDa and the accession number is P16310-1.
TMPY-02007 GHR/Growth Hormone R Protein, Rat, Recombinant (His) Rat HEK293 Cells
GHR/Growth Hormone R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.6 kDa and the accession number is P16310-1.
TMPY-00977 GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc) Mouse HEK293 Cells
GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is Q3UP14.
TMPY-01448 GHR/Growth Hormone R Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
GHR/Growth Hormone R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.3 kDa and the accession number is Q3UP14.
TMPJ-00356 GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth,...
TMPY-00186 GHRH Protein, Human, Recombinant (hFc) Human HEK293 Cells
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important...
TMPH-03204 GHR Protein, Rabbit, Recombinant (His & Myc) Rabbit E. coli
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon...
TMPH-03112 GHR Protein, Pig, Recombinant (His) Sus scrofa (Pig) E. coli
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon...
TMPH-02440 GHR Protein, Rhesus macaque, Recombinant (His) Rhesus E. coli
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon...
TMPH-02522 GHRL Protein, Mouse, Recombinant (His) Mouse E. coli
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid se...
TMPK-00806 GHR/Growth Hormone R Protein, Human, Recombinant (His) Human HEK293 Cells
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual f...
TMPH-01528 IHH Protein, Human, Recombinant (His) Human E. coli
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target gen...
TMPJ-00366 GAS6 Protein, Human, Recombinant (hFc) Human HEK293 Cells
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds...
TMPJ-00080 IL-11 Protein, Human, Recombinant (P. pastoris) Human P. pastoris (Yeast)
Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that dir...
TMPY-04999 GAS6 Protein, Human, Recombinant (His)
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds...
TMPJ-00577 INSL3 Protein, Human, Recombinant (His) Human HEK293 Cells
Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene. It is a secreted protein that belongs to the insulin family. It is expressed in prenatal and postnatal Leydig cells and found as well in the corpus...
TMPJ-00365 GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated Human HEK293 Cells
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signa...
TMPJ-00271 SMAD3 Protein, Human, Recombinant (His & Flag) Human E. coli
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so...
TMPH-02274 JAK2 Protein, Human, Recombinant (His) Human E. coli
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cyto...
GHR/Growth Hormone R Protein, Rat, Recombinant (hFc)
TMPY-04281
Species: Rat
Expression System: HEK293 Cells
GHR/Growth Hormone R Protein, Rat, Recombinant (His)
TMPY-02007
Species: Rat
Expression System: HEK293 Cells
GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc)
TMPY-00977
Species: Mouse
Expression System: HEK293 Cells
GHR/Growth Hormone R Protein, Mouse, Recombinant (His)
TMPY-01448
Species: Mouse
Expression System: HEK293 Cells
GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc)
TMPJ-00356
Species: Mouse
Expression System: HEK293 Cells
GHRH Protein, Human, Recombinant (hFc)
TMPY-00186
Species: Human
Expression System: HEK293 Cells
GHR Protein, Rabbit, Recombinant (His & Myc)
TMPH-03204
Species: Rabbit
Expression System: E. coli
GHR Protein, Pig, Recombinant (His)
TMPH-03112
Species: Sus scrofa (Pig)
Expression System: E. coli
GHR Protein, Rhesus macaque, Recombinant (His)
TMPH-02440
Species: Rhesus
Expression System: E. coli
GHRL Protein, Mouse, Recombinant (His)
TMPH-02522
Species: Mouse
Expression System: E. coli
GHR/Growth Hormone R Protein, Human, Recombinant (His)
TMPK-00806
Species: Human
Expression System: HEK293 Cells
IHH Protein, Human, Recombinant (His)
TMPH-01528
Species: Human
Expression System: E. coli
GAS6 Protein, Human, Recombinant (hFc)
TMPJ-00366
Species: Human
Expression System: HEK293 Cells
IL-11 Protein, Human, Recombinant (P. pastoris)
TMPJ-00080
Species: Human
Expression System: P. pastoris (Yeast)
GAS6 Protein, Human, Recombinant (His)
TMPY-04999
Species:
Expression System:
INSL3 Protein, Human, Recombinant (His)
TMPJ-00577
Species: Human
Expression System: HEK293 Cells
GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00365
Species: Human
Expression System: HEK293 Cells
SMAD3 Protein, Human, Recombinant (His & Flag)
TMPJ-00271
Species: Human
Expression System: E. coli
JAK2 Protein, Human, Recombinant (His)
TMPH-02274
Species: Human
Expression System: E. coli
Cat No. Product Name
L2191 Anti-Breast Cancer Compound Library

1939 compounds
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study;
TargetMol