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Cat No. | Product Name | Synonyms | Targets |
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T17103 | TM-N1324 | Others , GHSR | |
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s... | |||
T4648 | TC-G-1008 | GPR39-C3 | GHSR |
TC-G-1008 (GPR39-C3) is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). | |||
TQ0022 | Capromorelin Tartrate | CP 424391-18 | GHSR |
Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a). | |||
T16508 | PF-5190457 | PF-05190457 | GHSR |
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36). | |||
T10319 | Anamorelin | RC-1291,ONO-7643 | GHSR |
Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay). | |||
T7112 | Ibutamoren Mesylate | MK-0677,MK-677 | GHSR |
Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. | |||
T7225 | AnaMorelin hydrochloride | RC-1291 hydrochloride,ONO-7643 hydrochloride | GHSR |
AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay). | |||
T34281 | Relamorelin | BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131 | GHSR |
Relamorelin (RM-131), a selective and potent growth hormone-releasing peptide/growth hormone secretagogue receptor (GHSR) agonist, is a potent growth hormone-releasing peptide mimetic with a high affinity for the GHS-1a ... | |||
TP2236L | Cortistatin-8 acetate | Cortistatin-8 acetate(485803-62-1 Free base) | GHSR |
Cortistatin-8 acetate is a corticosteroid analog, a GHS-R antagonist with inhibitory effects on the growth hormone pro-secretin receptor.Cortistatin-8 acetate is a synthetic corticosteroid-derived ligand for the growth h... | |||
TP1155L | Human growth hormone-releasing factor acetate | GHSR | |
Human growth hormone-releasing factor acetate is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1]. | |||
T11719 | JMV 2959 hydrochloride (925238-89-7 free base) | JMV 2959 hydrochloride | GHSR |
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. | |||
T3630 | Relugolix | RVT-601,TAK-385 | GNRH Receptor |
Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi... | |||
TP1570 | Cortistatin-14 | Somatostatin | |
Cortistatin-14, a neuropeptide structurally similar to growth inhibitor-14, has anticonvulsant and neuroprotective effects and impairs recognition memory consolidation in mice through activation of sst(2), growth hormone... | |||
T1167 | Cyproterone acetate | Androcur,Cyproterone 17-O-acetate | Androgen Receptor |
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ... | |||
T11798 | L-692429 | MK-0751 | GHSR , GPCR19 |
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by glucocorticoids.L-692429 has a high affinity for the G prot... | |||
T31734 | BMS-604992 | EX1314,EX-1314 HCl,EX-1314,BMS604992,EX-1314 hydrochloride, BMS-604992,EX 1314 | |
EX-1314 (BMS-604992) is a growth hormone secretagogue receptor (GHSR) agonist. | |||
T28812 | SM-130686 | SM 130686,SM130,686,SM 130,686 | |
SM-130,686 is a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue. It has around half the potency of the endogenous agonist ghrelin as a stimulator o... | |||
T75713 | Human growth hormone-releasing factor TFA | ||
Human Growth Hormone-Releasing Factor TFA, also known as Growth Hormone-Releasing Factor Human TFA, is a hypothalamic polypeptide that promotes the production and release of growth hormone (GH) through its interaction wi... | |||
T76318 | GHRF, porcine | ||
GHRF, porcine, a growth hormone releasing factor (GHRF) peptide (porcine), binds to the growth hormone secretagogue receptor (GHSR), thereby inducing the release of growth hormone [1] [2]. | |||
T11719L | JMV 2959 | Others | |
JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM). | |||
TP1155 | Human growth hormone-releasing factor | Growth Hormone Releasing Factor human | |
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothal... | |||
T76317 | [His1,Nle27] GHRF (1-32), amide, human | ||
[His1,Nle27] GHRF (1-32), amide, human is a synthetic analog of the growth hormone-releasing hormone (GHRH), characterized by its enhanced affinity for the growth hormone-releasing hormone receptor (GHRHR) [1]. | |||
T28366 | PF-04628935 | PF 04628935,PF 4628935,PF4628935,PF04628935,PF-4628935 | |
PF-04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. PF-04628935 is orally bioavailable and brain penetrant. | |||
T35793 | JMV3002 | JMV3002 | |
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrel... | |||
T39236 | Relamorelin acetate | Relamorelin acetate,RM-131 acetate,BIM-28131acetate | |
Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki v... | |||
T75157 | Cimdelirsen | ||
Cimdelirsen, a novel ligand-conjugated, hepatic-targeted antisense oligonucleotide under investigation, aims to diminish growth hormone receptor (GHr) synthesis. This inhibits the harmful effects of growth hormone (GH) h... | |||
T68276 | Macimorelin acetate | EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate | |
Macimorelin Acetate (EP-1572), an orally active growth hormone (GH) secretagogue and a ghrelin receptor (GHSR) agonist, stimulates GH release. It is utilized in research focusing on adult growth hormone deficiency (AGHD)... | |||
T75157L | Cimdelirsen sodium | ||
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH... | |||
T82498 | Eftansomatropin alfa | ||
Eftansomatropin alfa, an antibody that targets the growth hormone receptor (GSH), is a fusion protein comprising GH1 and the Fc region of IGHG4 [1]. | |||
T38959 | BMS-604992 dihydrochloride | EX-1314 dihydrochloride,BMS-604992 dihydrochloride | |
BMS-604992 (EX-1314) dihydrochloride is a selective and orally active small-molecule agonist of the growth hormone secretagogue receptor (GHSR). It exhibits high-affinity binding (k i = 2.3 nM) and potent functional acti... | |||
T40876 | BMS-604992 free base | BMS-604992 free base,EX-1314 free base | |
BMS-604992 (EX-1314) free base is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. It exhibits high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.... | |||
T64119 | SSTR5 antagonist 2 hydrochloride | ||
SSTR5 antagonist 2 hydrochloride is a potent, orally active, selective growth hormone inhibitory hormone (receptor) subtype 5 (SSTR5) antagonist that has shown potential for investigation in type 2 diabetes. | |||
T83756 | S1H TFA | Site 1-binding Helix | |
S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered b... | |||
T35524 | (1S)-Calcitriol | ||
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3), a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), exerts potent actions through vitamin D receptor (VDR) activation, including the inhibition of keratin... | |||
T37412 | AZ-GHS-22 | ||
AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in ... | |||
T75262 | Relamorelin TFA | ||
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, acts as a potent and selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR), with a K_i of 0.42 nM for the GHS-1a receptor. This compound is... | |||
T75928 | Des-Gln14-Ghrelin TFA | ||
Des-Gln14-Ghrelin TFA serves as a potent endogenous ligand for the growth hormone secretagogue receptor, effectively inducing increases in intracellular calcium levels ([Ca2+]i) in CHO-GHSR62 cells with an EC50 of 2.4 nM... | |||
TP1532 | γ-2-MSH (41-58), amide | ||
Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cel... | |||
T78003 | [D-p-Cl-Phe6,Leu17]-VIP TFA | ||
[D-p-Cl-Phe6,Leu17]-VIP TFA acts as a competitive and selective antagonist of the vasoactive intestinal peptide (VIP) receptor, exhibiting an IC50 of 125.8 nM. It shows no activity on glucagon, secretin, or growth hormon... |
Cat No. | Product Name | Synonyms | Targets |
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T7931 | 16a,17a-Epoxy-4-Pregnen-3,20-Dione | Others | |
16a,17a-Epoxy-4-Pregnen-3,20-Dione is a synthetic progestin, a metabolite of the luteinizing hormone hormone, which acts by binding to the luteinizing hormone receptor. It has been used to study the effects of progestero... | |||
T80006 | Emoghrelin | GHSR | |
Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1]. | |||
T82277 | GM1a Ganglioside oligosaccharide | ||
GM1a Ganglioside oligosaccharide, a semisynthetic derivative of ganglioside GM1, serves as the natural receptor for cholera toxin and is crucial for both general growth regulation and the coupling of hormone-induced resp... |
Cat No. | Product Name | Species | Expression System |
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TMPY-04281 | GHR/Growth Hormone R Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
GHR/Growth Hormone R Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55.4 kDa and the accession number is P16310-1. | |||
TMPY-02007 | GHR/Growth Hormone R Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
GHR/Growth Hormone R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.6 kDa and the accession number is P16310-1. | |||
TMPY-00977 | GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is Q3UP14. | |||
TMPY-01448 | GHR/Growth Hormone R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
GHR/Growth Hormone R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.3 kDa and the accession number is Q3UP14. | |||
TMPJ-00356 | GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth,... | |||
TMPY-00186 | GHRH Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important... | |||
TMPH-03204 | GHR Protein, Rabbit, Recombinant (His & Myc) | Rabbit | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon... | |||
TMPH-03112 | GHR Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon... | |||
TMPH-02440 | GHR Protein, Rhesus macaque, Recombinant (His) | Rhesus | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon... | |||
TMPH-02522 | GHRL Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid se... | |||
TMPK-00806 | GHR/Growth Hormone R Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual f... | |||
TMPH-01528 | IHH Protein, Human, Recombinant (His) | Human | E. coli |
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target gen... | |||
TMPJ-00366 | GAS6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds... | |||
TMPJ-00080 | IL-11 Protein, Human, Recombinant (P. pastoris) | Human | P. pastoris (Yeast) |
Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that dir... | |||
TMPY-04999 | GAS6 Protein, Human, Recombinant (His) | ||
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds... | |||
TMPJ-00577 | INSL3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene. It is a secreted protein that belongs to the insulin family. It is expressed in prenatal and postnatal Leydig cells and found as well in the corpus... | |||
TMPJ-00365 | GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells |
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signa... | |||
TMPJ-00271 | SMAD3 Protein, Human, Recombinant (His & Flag) | Human | E. coli |
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so... | |||
TMPH-02274 | JAK2 Protein, Human, Recombinant (His) | Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cyto... |
Cat No. | Product Name | ||
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L2191 | Anti-Breast Cancer Compound Library | 1939 compounds | |
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; |